hepatoprotective effects of pentoxifylline against acrolein- induced mitochondrial dysfunction in rat liver

نویسندگان

jamshid karimi department of biochemistry, school of medicine, hamadan university of medical sciences, ‎hamadan, iran.‎

akram ranjbar department of toxicology and pharmacology, school of pharmacy, hamadan university of ‎medical sciences, hamadan, iran.‎

heidar tavilani‎ department of biochemistry, school of medicine, hamadan university of medical sciences, ‎hamadan, iran.‎

چکیده

acrolein (acr) is α, β unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. it can also be generated through endogenous metabolism. the aim of this study was to investigate the possible protective role of pentoxifylline (ptx) is a non-selective phosphodiesterase (pde) inhibitor on toxicity of acr. in this study, oxidative damage were measured by markers liver mitochondrial, such as, glutathione peroxidase (gpx), superoxide dismutase (sod), lipid peroxidation (lpo) and total glutathione (gsh) in rats. effective doses of acr ( 2mg/kg/day ) and ptx (50mg/kg/day) and vitamin e ( 15mg/kg/day ) were administered alone or in combination for 14 days by intraperitoneal injection. at the end of the experiment, the liver mitochondria of the animals were separated. ptx ameliorated lpo, sod and gpx in liver mitochondria of acr-induced changes. co-administration of ptx with acr improved lpo in liver mitochondria. in conclusion, intracellular camp-elevating agents like ptx, may be considered beneficial for the protection or recovery of acr-induced toxic damage in liver mitochondria.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

hepatoprotective effects of vitamin e against malathion-induced mitochondrial dysfunction in rat liver

conclusions in conclusion, at measurement can be beneficial for the safety or recovery of malathion-induced toxic injury in liver tissue and liver mitochondria. results in liver tissue, the activity of lpo and cat was higher in the malathion group in comparison to controls. at reduced malathion-induced lpo, sod, cat, and gpx in rat liver. coadministration of at with malathion improved lpo, sod,...

متن کامل

Comparison of the Protective Effects of Curcumin and Nanocurcumin on Acrolein Induced Mitochondrial Toxicity Isolated from Rat Liver

Background and Objectives: Contact with acrolein rapidly reduces intracellular glutathione and its antioxidant capacity and causes mitochondrial dysfunction. The use of some polymeric nanocurcumin increases the stability of curcumin. In this study, the effect of these two, was investigated on acrolein-induced toxicity in mitochondria isolated from rat liver cells.   Methods: In this experiment...

متن کامل

The pretreatment effects of pentoxifylline on aflatoxin B1-induced oxidative damage in perfused rat liver

This study was conducted to investigate the hepatoprotective and antioxidant effects of pentoxifylline (PTX) against aflatoxin B1 (AFB1) exposure in perfused rat livers by evaluating damage marker enzymes, antioxidant defense systems (glutathione, GSH) and lipid peroxidation (malondialdehyde, MDA). Sixteen rats were divided randomly into four experimental groups: control, PTX, AFB1 and AFB1 + P...

متن کامل

The Hepatoprotective Effects of Corn Silk against Dose-induced Injury of Ecstasy (MDMA) Using Isolated Rat Liver Perfusion System

Background: Corn silk (CS) is widely used in Iranian traditional medicine. The aim of this study was to investigate hepatoprotective activity of CS by Isolated Rat Liver Perfusion System (IRLP). Methods: Hydro-alcoholic extract of corn silk (10, 20, 40, and 100 mg kg-1) was evaluated for its hepatoprotective activity by IRLP. Phenol and flavonoid contents of the extract were determined as gal...

متن کامل

Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver

Objective(s): Recognized as a distinguished environmental and global toxicant, Bisphenol A (BPA) affects the liver, which is a vital body organ, by the induction of oxidative stress. The present study was designed to investigate the protective effect of quercetin against BPA in hepatotoxicity in Wistar rats and also, the activity of mitochondrial enzymes were evaluated...

متن کامل

Hepatoprotective effects of purified oleuropein from olive leaf extract against ethanol-induced damages in the rat

Olives and olive oil contain large amounts of oleuropein. This phenolic compound is responsible for theirbitter taste and pungent aroma and has been recognized as a powerful hypotensive, hypoglycemic andantioxidant agent. Thus, the aim of the present study was to evaluate the antioxidant properties of oleuropein on ethanol-induced oxidative damage and to examine its beneficial effects on liver ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
journal of reports in pharmaceutical sciences

جلد ۳، شماره ۱، صفحات ۱۹-۲۷

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023